Hello Mike,
can you tell us what version of the Men & Mice software you are using? Is the Windows 2008 System a 32bit or 64bit system?
You can try to start the Men & Mice Central process in debug mode, that should print out the root cause of this issue:
Open a command line window, navigate to the Men & Mice Central installation directory, then start the Men & Mice Central with this line
Code:
mmcentral.exe -debug -ll5
where the last parameter is two times the lowercase letter "L" and then the digit five (for Log-Level 5).